Microbiology and Immunology 3820A Lecture Notes - Lecture 11: Hepatitis B, Exanthem, Serostatus

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Seasonality and short incubation periods (1-4 days) Surface proteins: hemagglutin (15 subtypes binds to oligosaccharide (on cell surface) containing terminal sialic acids), neuraminidase (9 subtypes) Humana and swine influenza a (& b,c) bind to n- acetylneuraminic acid a2, 6 galactose which human cells have. Avian and equine influenza a bind to to n-acetylneuraminic acid a2,3 galactose. Swine have both a2,3 and a2,6 galactose receptors, susceptible to all influenza strains. Pb1-f2 protein: binds to inner mitochondrial membrane, sensitizes cells to apoptotic stimuli, inflammatory, may down regulate immune response significant. A can infect poultry, swine, horses and humans. B- infect only humans have never caused pandemics. Seasonal influenza: start in far east possibly due to agrarian practices in china (china gets in spring, we get in fall) H1n1: only h5 and h7 can be virulent in birds. 1889 h2n2: deadly in young and healthy. Rapid tests for viral antigen in nasal secretions widely available. Out breaks interrupted by admin zanamivir and oseltamivir.

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