Microbiology and Immunology 3820A Lecture Notes - Lecture 5: Rectum, Fallopian Tube, Cytoplasmic Inclusion

• School: Western University
• Department: Microbiology and Immunology
• Course: Microbiology and Immunology 3820A
• Professor: David Colby

Document Summary

Unable to synthesize atp - (cid:862)e(cid:374)ergy parasites(cid:863) Structurally similar to small gram negative bacteria except no peptidoglycan. Intracellular form is the reticulate body (not homogenous, little markings) Rb divides repeatedly by binary fission 48h until a large cytoplasmic inclusion is formed (blob of them inside host cell) Rb"s (cid:272)o(cid:374)de(cid:374)se to for(cid:373) ele(cid:373)e(cid:374)tary (cid:271)odies (cid:449)hi(cid:272)h are released i(cid:374)to the e(cid:374)(cid:448)iro(cid:374)(cid:373)e(cid:374)t (cid:271)y lysis of the host cell. Eb"s are phago(cid:272)ytosed (cid:271)y differe(cid:374)t sus(cid:272)epti(cid:271)le host (cid:272)ells. Eb prevents fusion of phagosome and lysosome digestive enzymes are avoided in host cell. The eb reorganizes into the larger rb happens all over again. Inclusion bodies stain with iodine: chlamydia trachomatis. Two groups of serovars that cause different syndromes: A to c trachoma biovar (d - - k commonly cause genital tract infections in n. america. L1, l2, l2a & l3 lymphogranuloma venereum biovar. Serovars a, b, ba & c most common. Chronic infection leads to scarring and trichiasis (turning in of eyelids)