Microbiology and Immunology 3300B Lecture Notes - Lecture 4: Tlr9, Transforming Growth Factor Beta, Ccl4
3 Mar 2018
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Metabolites produced by bacteria (fmlp): recognized by immune system. Dsrna: (cid:449)e do(cid:374)"t ha(cid:448)e dsrna (cid:894)ha(cid:448)e ssrna or dsdna(cid:895) when detected, something is wrong. Endosomal rna or dna: location of recognition site very important; all our dna in nucleus, rna in cytoplasm. If find dna or rna in wrong places identified by prr i. e. if dna or rna in endosome recognize by prr because it should not be there. Cpg dna (cid:858)odd(cid:859) na (e. g. uncapped rna: recognize peculiar rnas like uncapped rna (we always cap rna to aid translation & rna stability, viral rnas are uncapped no need to cap. Fungal pamps fungi = eukaryotic organisms (more closely related to us so less pamp for recognition) B-glucan (polysaccharide) (both recognized by immune system as pamp) Profilin (we also make profiling but ours is significantly different; profiling is an actin binding protein involved in the dynamic turnover and restructuring of the actin cytoskeleton found in all euk in most cells)
