Microbiology and Immunology 2500A/B Lecture Notes - Lecture 1: Mhc Class Ii, Major Histocompatibility Complex, Cytotoxic T Cell

• School: Western University
• Department: Microbiology and Immunology
• Course: Microbiology and Immunology 2500A/B
• Professor: Dimitrios J Dikeakos, John Mc Cormick, Kelly Lynn Summers

Document Summary

Helper t lymphocytes (th cells; cd4 + t cells) Cytotoxic t lymphocytes (ctl; cd8 + t cells) Note: tcr remains bound to surface of t cell, unlike bcr which gets secreted as an antibody (soluble form) Primary response generates effector t cells from na ve t cells. Na ve t cell binds to its specific epitope on a dc which induces clonal expansion. All those daughter cells become effector t cells: na ve helper t cell effector helper t cell . Memory effector helper t cell: na ve cytotoxic t cell effector cytotoxic t cell memory effector cytotoxic t cell. All have one fate (effector t cell). Unlike how na ve b cells differentiate become short-lived plasma cells, long-lived plasma cells or memory cells. After the pathogen is cleared, some effector t cells remain as memory effector t cells. Why do some effector t cells die by apoptosis and some remain as memory effector t cells.