Microbiology and Immunology 2500A/B Lecture Notes - Lecture 32: Rheumatic Fever, Streptococcal Pharyngitis, Heart Failure
25 Jan 2017
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Document Summary
Red sores that forms crusts, normally on the face. Rash that develops typically during strep throat. Toxin mediated - caused by the (cid:498)scarlet fever toxins(cid:499) Occurs 2-3 weeks after infection (e. g. strep throat or scarlet fever) Typically occurs in children 5-15 years of age. A form of autoimmunity caused by antibody cross-reactivity with the m protein. Acute rheumatic fever the initial inflammation can cause painful swollen joints. Rheumatic heart disease damaged heart valves. Patients are at increased risk for infective endocarditis by other pathogens. Rare in developed counties since 1960s but endemic in many developing countries. Rare in developed countries but very serious (cid:498)invasive streptococcal disease(cid:499) is defined as isolation of s. pyogenes from a normally sterile site. Chicken pox in children (58-fold increased risk) Lack of immunity to superantigens and m protein. Mhc class ii haplotypes (ie. superantigen receptors) The major burden of disease occurs in developing countries. > 600 million cases of strep throat.
