Microbiology and Immunology 2500A/B Lecture Notes - Lecture 10: Cytotoxic T Cell, Mhc Class I, Mhc Class Ii
15 Jan 2017
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Document Summary
Are called effector cells because they are the ones that will return to fight the infection. Have chemokine receptor that allow them to be attracted to the infected tissue. Effector t cells are the only ones that can enter into inflamed peripheral tissue (naive ones can"t) Ctl and nk cell is not destroyed or injured. After a significant amount of them effector ctl comes as well triggers effector ctl to release perforin and granzymes (same as nk!) Makes pores in pathogen and destroy dna of cell (and virus) induce apoptosis in infected cell, stop replication of virus. Some viruses evade ctl response by blocking peptide presentation by mhc class i molecules. Block the production of the peptides by preventing the protein from entering the proteasome. Block the binding of the peptide onto the mhc i. Only nk cells can kill these types of infection. To negate this, dc can present exogenous viral peptides on both mhc i and.
