Microbiology and Immunology 2500A/B Lecture Notes - Lecture 12: Alexandre Yersin, Proventriculus, Sepsis
15 Jan 2017
School
Department
Professor
Document Summary
Death in 2-4 days after showing symptoms. Patient experience sudden onset of fever, chills, headaches, muscle pain, weakness. Painful swelling (buboes) of lymph nodes in the armpits, legs, neck, groin. Size of an apple, can break open, intense pain. High fever, delirium and mental deterioration, large pustules that burst, blood vomiting, bleeding in the lungs. Started in the 6th century (541-542 ad) Spread to mediterranean, italy, and throughout europe. Continuous cycles of widespread infection until about 750 ad then disappeared for about 800 years. Not a one time thing, new outbreak comes in waves. Reservoir in rats, returns, infects and kills. A medieval pandemic caused by yersinia pestis. Different strain than the one causing the plague of justinian. Originated in asia and reached europe in the late 1340. Reduced the global population from about 450 million to 350-375 million. Killed about 25 million europeans (1/3 of the total population)
