Microbiology and Immunology 2500A/B Lecture Notes - Lecture 10: Minimum Inhibitory Concentration, Penicillin Binding Proteins, Glycopeptide Antibiotic

• School: Western University
• Department: Microbiology and Immunology
• Course: Microbiology and Immunology 2500A/B
• Professor: Dimitrios J Dikeakos, John Mc Cormick, Kelly Lynn Summers

Document Summary

Alexander fleming: discovered penicillin in 1928, produced from penicillium, left out a petri dish of staph colonies of staphylococci couldn"t grow around a contaminating mold, nobel prize in physiology and medicine (1945) Antibiotics: antibiotics represent our most effective therapeutic against bacterial infections, the availability of antibiotics enables cancer chemotherapy, organ transplantation, all invasive surgeries, treatment of premature infants, cancer targets cells that are dividing. Cells become immunosuppressed and antibiotics are necessary to help prevent infection: organ transportation: susceptibility to infections - requires antibiotics. Antibiotics either kill bacteria, or stop them from growing: bacteriocidial: kill bacteria, bacteriostatic: the immune system must eventually kil l the bacteria but stop for now. Measuring antibody activity: minimum inhibitory concentration (mic), series of culture tubes with varying concentration of agent, check for visible growth, at the amount in concentration where the bacteria can no longer grow you hit mic.