Kinesiology 2230A/B Lecture 4: Glycolysis

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Glycolysis - the breakdown of glucose to pyruvic acid (pyruvate) Glycogenolysis - the breakdown of glycogen to glucose. Glycolytic system - cho: glucose concentrations in the blood are highly regulated by the pancreas via insulin and glucagon, pancreas consists of 2 different cells, beta cells: Type 1: genetic disease, expressed early in life, no insulin production. Insulin is produced but does not stimulate the uptake of glucose into the cell. Initial glucose (6c) splits into 3c units: each one gets phosphorylated and becomes 2 pyruvates, depending on the intensity of the activity, the 2 pyruvates can become 2 lactate. Nadh regeneration: nad is a cofactor which can accept hydrogens, lactate dehydrogenase. It can be regenerated (oxidized - loss of h) in 2 ways: allows us to form lactate from pyruvate (anaerobic, shuttle systems connecting to mitochondria. If nad was not regenerated, glycolysis could not proceed beyond g3p, and no atp would be generated. Lactate: has 80% of original glucose energy.

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