Kinesiology 1070A/B Lecture Notes - Lecture 11: Functional Magnetic Resonance Imaging, Major Depressive Episode, Translocator Protein
27 Sep 2018
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Case study: mood linked responses in medial prefrontal cortex predict relapse in patients with recurrent unipolar (norman, anderson, bloch, segal) Got 16 formerly depressed people to watch movie clips and mapped brain activity. 9 people relapsed into depression and they compared those to people who had never been depressed before. Relapsed patients showed more activity in the medial prefrontal gyrus. Relapse is a problem with depression (we are researching why) Having a biomarker for relapse could give new treatment research. Case study: role of translocator protein density, a marker of neuroin ammation, in the brain during major depressive episodes. Level of protein is increased in the microglia cells= higher translocator protein density. Participants: 20 people with a major depressive episode and 20 healthy controls. Discovered that higher in ammation in all areas of the brain is seen in people with depression. Unable to determine whether the neuroin ammation occurs before depression or because of it.
