Geography 2152F/G Lecture Notes - Lecture 9: Lipophilicity, Pharmacogenetics, Gs Alpha Subunit
9 Nov 2017
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Example is putting a outlet cover on the plug it is tough to unbind once it is bound covalent bond that cant be removed unless you form a new platelette. Binds to the protein and changes the conformation of the receptor at the binding site making it so the ligand or drug cannot bind the protein. Chemical antagonists: attack the agonist by binding it and not allowing it to bind to a receptor. Functional antagonists: have the opposite physiological effects to the agonist. How do drug receptor complexes cause a biological response. A lot of the effects are mediated by the phosphorylation of the protein. An agonist for this receptor is nicotine. Provides a pore for a different ion. Making the inside of the cell more negative. Spans the membrane 7 times (7 transmembrane spanning domains) When drug or ligand binds to the receptor it causes a conformational change to the receptor. This allows the interaction with the gs protein.
