Biology 3601A/B Lecture Notes - Lecture 13: Transient Receptor Potential Cation Channel, Member A1, Trpm8, Trpv1

• School: Western University
• Department: Biology
• Course: Biology 3601A/B
• Professor: Brent Sinclair

Document Summary

Need to be able to detect the temperature to maintain a set body temperature. Detect temperature to determine if something is got and is going to hurt us. Thermoregulate by choosing different types of habitats (shade, sun) commonly done by ectotherms. Trp (transient receptor potential) family (cations) 28 in humans: active ingredient in chili peppers and bear spray if you stop activating receptor, you stop feeling the pain. Trpmb menthol (cool: antagonize receptors that are normally only activated when temperatures are low. Work when purified and inserted back into membranes (i. e. : no protein cofactors required) Thermosensory behaviour is modified in rhodopsin mutants, but likely because of behavioral, rather than sensing issues. These usually function as temperature-gated ion channels. Heat you get from capsaicin is different than what you get from mustards. Thermoreception in mammalian skin: firing rate decreases at lower and higher temperatures, activated by menthol. Cold fibers ongoing action potentials at (cid:494)normal(cid:495) temps.