Biology 3597A/B Lecture 7: Eukaryotic Gene Transcription II
25 Jan 2020
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Document Summary
Transcription machinery the general transcription machinery in eukaryotes is much more complex than in prokaryotes elaborate multi protein complexes required for promoter recognition. Rna synthesis the general transcription machinery consists of three components. Rna polymerase 11 many studies performed on rna polymerase. C - terminal domain ( ctd ) of. Rpbl is not seen by x - ray crystallography. I i the catalytic core catalyzes the formation. Of rna and can do proofreading the dimer helps recognize promoters the. C - terminal domain is very important in transcription. Ctd gets phosphorylated by many different regulatory proteins. C ctd ) tail like feature of the largest subunit consists of up to 52 he pta peptide repeats undergoes dynamic phosphorylation of serine residues transcription initiation requires an un phosphorylated. Starts in eukaryotes general transcription factors are listed big difference in initiation between prokaryotes and eukaryotes eukaryotes require the formation of the pre - initiation complex.
