Biology 3597A/B Lecture Notes - Lecture 18: Release Factor, Integral Membrane Protein, Eif2
5 Apr 2017
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Document Summary
The rna world in rna world the rna molecule serves 2 functions: stores information (like dna, catalyzes reactions (like protein) Rna which is able to synthesize small proteins. Rna replaced by protein for catalysis: protein does the job better. Rna replaced by dna for information storage: dona does the job better. Rna was kept in middle as intermediate between the two. Alternate conformations have different biochemical properties: one of the functions is ligase function joins two pieces dna together, other is nuclease (dna cleavage) function endonuclease. 1 ribozyme with 2 functions: structure determines function, over time you see smaller digested product, the 3d structure of ribozymes play role in overall function. A ribozyme which can polymerase 100% of its length. 4 proof of principle: rna could self-replicate. Synthesized ribozyme that can polymerase 100% of its own length equal or greater number of nucleotides then its own length.
