Biology 1202B Lecture Notes - Lecture 23: Lysis, Passive Immunity, Innate Immune System

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Third line of defence unique to vertebrates. B and t cells are specific for a particular antigen. Mediated by antibodies and also mediated by cells (cytotoxic t cells) Similar steps: lymphocyte encounters antigen, binds to antigen gets activated and proliferated, cell divides, antigen clearance, development of immunological memory. B cell receptor and antibodies are the same, but b cell receptor has a transmembrane portion. Outcome whole bunch of b cells with different variable regions: same constant region. A dendritic cell becomes an antigen presenting cell (apc) An apc presents an antigen to cd4+ t cell. T cell binds to dendritic cell at cd4 receptor. Displays the molecules on the cell surface (proteins, carbohydrates, etc. ) Encounter leads to proliferation of b cells clonally amplify. This response is amounted to one aspect of bacteria. Not just one antigen on a bacteria bacteria is being attacked from multiple fronts not happening at one time.

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