Biology 1002B Lecture Notes - Lecture 24: Operon, Cell Membrane, Experimental Evolution
31 May 2016
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Most studies of evolution are constrained by two facts: most organisms evolve slowly, can"t go back in time to examine ancestral forms. Model systems for experimental evolution: viruses, bacteria, chlamy, drosophila, yeast (short generation time) Comparing ancestral and evolved strains: start with single genotype of e. coli. Split the population add a neutral gene to one population making it red. Adaptation after 2000 generations: grow e. coli 2000 generations at 32 or 42, compare to ancestors grown at 37. Results show that e. coli 32 adapt (no a big w at 32) E. coli 42 adapt very well (has a huge w at 42) E. coli can live in low temperatures, not high. What experiment can we do sequencing & alignment: non-synonymous mutations probably in enzyme that affected the growth. Long term evolution experiment (lee: can evolution produce adaptation if it depends on random mutations (most of which are harmful), lenski group msu.
