Biology 1002B Lecture Notes - Lecture 17: Cyclin-Dependent Kinase 2, Microrna, Genotype
31 May 2016
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Document Summary
Maternal effect genes are expressed in the mother: segmentation genes are first to be expressed in zygote. One of the mechanisms of epigenetic control is chromatin remodeling by methylation of dna. Dna methylation can silence genes in 2 ways: if dna gets methylated, it can directly block the binding of a transcription factor, methylation can also attract a chromatin remodeling complex. Brings h stacks close downs chromatin. Epigenetic no change in dna sequence (x- chromosomes in women) permanent change. Hallmarks of cancer: sustaining proliferative signaling, evading growth suppressor, activating invasion and metastasis, enabling replicative immortality, inducing angiogenesis, resisting cell death (apoptosis) In canada, men are at higher risk of cancer than women hormones are relevant: colon (prostate) cancer, breast cancer, lung cancer. The definition of heritability is the proportion of phenotypic variation that arises from genotypic variation: cancer heritability is 0. 27-0. 42.
