Biology 1002B Lecture Notes - Lecture 17: Microrna, Tumor Suppressor Gene, P53

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amaranthreindeer718

7 Apr 2016

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Lecture 17









o







 

!"# 

 $



 %

&$'

o()$ 

 *$'

o!$$

o

$+,- 

o##$

o-./01/%)

#%*

o&$$/ 

%

o2#3 

- 4+5$

o6$)$*

o,7)*/



o6$)889.*

o9.$

 :+,-/4+5

o;,-$

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<<$

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Document Summary

Colorectal cancer how to take precauions against preventable cancer. Can be linked to development of cancer reasons why idenical twins may have diferent cancer incidence. If one idenical twin gets cancer should the other be concerned? o o o. Comparison in methylaion of dna between twins over ime o o o o. Paterns on gel show the paters of methylaion. At age 3, almost idenical but at age 26, they are highly diferent (epigeneic paterns are diferent) If methylaion of genes is important in cancer, then they would have highly diferent risks. All cells have cyclin/cdk for regulaion the cell cycle o o o o o. Expression of proto-oncogenes promotes cell cycling (makes it occur faster) They are not cancer gene (no such thing), but they get de-regulated causing cancer. Expression of tumor suppressor genes slows cell cycling (i. e. p53)

Biology 1002B Lecture Notes - Lecture 17: Microrna, Tumor Suppressor Gene, P53

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