Biology 1002B Lecture Notes - Lecture 19: Mental Floss, Four Causes, Angiogenesis

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Types of genes that are the first to be transcribed in the nuclei of drosophila zygotes: maternal genes. Top four causes of death in developed world: breast cancer, prostate cancer, lung cancer, bowel cancer. There are different cancer rates across the provinces. There is not one singular cure for cancer, since it is not just one disease: cancer is a broad term for a bunch of different disease, cancer is us. Hallmarks of cancer: sustaining proliferative signalling, keep dividing, evading growth suppressors, ignoring slow down signals, activating invasion and metastasis, enabling replicative immortality, inducing angiogenesis, resisting cell death. Driver mutations confer a growth advantage on cells: cell growth and survival, reduced genome maintenance, cell fate, have usually a dedifferentiated ffate. Karyotypes of cancer cells are different than a typical cells: parts of entire chromosomes could be gone. Methylations: regions of genomes that are methylated, epigenetic marks, twins will have different levels of methylation as they get older.

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