Biology 1002B Lecture Notes - Lecture 9: Pyruvate Dehydrogenase Kinase, Dinitrophenol, Uncoupling Protein

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Do(cid:374)"t (cid:374)eed to k(cid:374)ow (cid:374)u(cid:373)ber of atp a(cid:374)d nadh (cid:373)ade. How metabolism is organized: catabolic pathways - not all reactions need to be exergonic, but when you add them up, the overall pathway is exergonic, ex. Cellular respiration: free energy from catabolic pathways is harnessed and used to make atp, anabolic pathways - not all reactions need to be endergonic, but when you add them up, the overall pathway is endergonic, ex. Protein synthesis (any synthesis reactions: atp are used to increase free energy of products. Four supermolecular complexes make up e- transport chain. Fmn, fe/s are cofactors, not proteins: they always get oxidized and reduced - they are redox active and what is actually transferring the e, proteins do not get oxidized and reduced - they just hold the cofactors. Uncoupling: etc pumps h+ into intermembrane space, h+ flows back into matrix through atp synthase pore. It also stimulates glycolysis which means carbohydrate consumption.

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