Biology 1002B Lecture Notes - Lecture 6: Sulfite Oxidase, Exergonic Reaction, Competitive Inhibition
9 Sep 2013
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Document Summary
Role of an enzyme (enzymes are proteins that proteins catalyst) Speed up reactions but don"t get consumed. Have to acquire transition state: where bonds are ready to break, gets energy from environment. Activation energy: amount of energy needed to get to the transition point: represents a barrier, prevents reaction from going very fast. Propane thermodynamically unstable, but kinetically stable- doesn"t have a tendency to combust with out help. Makes reactions faster: more molecules have energy to get to transition state. Only changes the path along which reaction takes place. Why does life need enzymes: we need to get reactions to go faster but heat destroys cells. Enzyme is very big, substrate is very small. Catalysis takes place in activation site of enzyme. Active site: specific part of enzyme where substrates bind: becomes apparent only after it fold to it native conformation. Fundamental: must be flexible, induced fit upon substrate binding: induced fit. E + s es e + p.
