Biology 1002B Lecture Notes - Lecture 23: Retina, Hoatzin, Molecular Evolution

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Synonymous mutations don"t result in changes in amino acid sequences; neutral: occur at a relatively constant rate over evolutionary time. Characteristics of the neutral theory of molecular evolution. Previously we thought that all mutations caused a change in protein sequence; this was the selection theory could be advantageous or deleterious (mostly deleterious) Now, comparing nucleotide to amino acid sequence has shown that most mutations are actually neutral (synonymous) This is gene evolution without natural selection. Relationship between frequency of amino acid substitutions in given proteins vs. time since common ancestor. Neutral mutations occur at a constant rate over time; number of neutral substitutions should be proportional to time. Can find the number of neutral differences in cytochrome c gene; based on that we can tell how long ago species diverged. Reflects a constant rate of mutation; more differences if two species diverged long ago.

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