Biology 1001A Lecture Notes - Lecture 9: Reciprocal Cross, Dna Repair, Organism

• School: Western University
• Department: Biology
• Course: Biology 1001A
• Professor: Tom Haffie

Document Summary

Arrangement of genes and alleles on homologous chromosomes in a dihybrid organism. How independent assortment creates 4 different products of meiosis from a dihybrid parent. Organism as whole produces 4 types of gametes. Application of the sum and product rule of probability. Sum rule: applies when several different events all give the same outcome (i. e. identifying the chance of getting pp in a monohybrid cross, you can get p from mom, p from dad, or p from mom, p from dad) Mechanisms that are, or are not, random with respect to generation of genetic diversity. Mobile elements are significant source of variation (300 places in genome) Tautomeric shifts allow alternative base pairing (single nucleotide polymorphisms) O(cid:373)e (cid:373)utage(cid:374)s a(cid:396)e tauto(cid:373)e(cid:396)i(cid:272)all(cid:455) u(cid:374)sta(cid:271)le (cid:271)ase (cid:862)analogues(cid:863) (cid:894)(cid:272)he(cid:373)i(cid:272)al (cid:373)utage(cid:374)esis(cid:895) Organisms ability to repair damage affects variability in genome (ex. Small in/del mutations during replication (copy number variation) Deletion, insertion, inversion, translocation (copy number variations) due to repair of double strand breaks.