Biology 1001A Lecture Notes - Lecture 7: Provirus, Mitosis, Comparative Genomics
1 Nov 2015
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Pre lecture: differences among insertion sequences, transposons, and retrotransposons, transposable elements are segments of dna that can move from one place to another. Their mechanism of movement, involving nonhomologous recombination in transposition. Cut and paste transposition te leaves one location in dna and moves to a new location. Copy and paste transposition te moves to new location, leaves original behind: bacterial te, insertion sequences, transposons. Simplest te, relatively small, only contains genes for transposase. Carries gene for transposase; catalyzes recombination of tes. Classified as recombinase, makes cuts in dna backbone. Repeated sequence of dna on either side of is running in opposite directions. This enables transposase enzyme to identify the ends of te when it catalyzes transposition. Has inverted repeat sequence at each end, enclosing a central region with one or more genes. In many bacteria the inverted repeats are is which contain transposase for movement of element.
