Biology 1001A Lecture Notes - Lecture 8: Copy-Number Variation, Dna Mismatch Repair, Pyrimidine Dimer
6 Mar 2017
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12. 4 mechanisms that correct replication error: proofreading mechanism: the dna polymerase reverses & removes mispaired bases on newly synthesises dna strand as a result of a replication error. 9. 4 mobile elements: both prokaryotic and eukaryotic organisms contain transposable elements (tes) dna sequences that can move from place to place in the dna. 2 kinds of transposition: copy & past; cut & paste (see figure. The parent copy remains at the original location. Like retrotransposons, retroviruses make a dna copy of their rna genome and insert this into the host"s chromosome. Retroviruses may have evolved from retrotransposons (see figure. 9. 20): te-instigated abnormal activation of genes regulating cell division has been linked to the development of some forms of cancer in humans and other complex animals. New strand slippage causes insertion (extra base) Template strand slippage causes deletion (loss of base) Regions of repeated sequence are particularly susceptible to in/del. Usually caused by tes: base analogues.
