Biology 1001A Lecture Notes - Lecture 12: Heterozygote Advantage, Allele Frequency, Zygosity
17 Feb 2017
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If there is a difference in tness between genotypes, then selection is happening. Absolute and relative tness: average number of surviving offspring for each genotype is de ned as its absolute tness (w) Eg waa=20 ,waa=15, waa=12: divide by absolute tness of most successful genotype to calculate relative tness (w, most successful genotype (wmax) has w=1. Fitness of an allele can depend on its relative abundance. Agents of microevolutionary change are things that will take a population out of hardy weinberg equilibrium: what if mating is not random with respect to genotype. Assortative (like pair with like) or dissassortative (opposites attract) mating. 250 aa, 500 aa, 250 aa---> 375 aa, 250 aa, 375 aa (no longer in hardy weinberg equilibrium: non random mating does not causes allele frequencies to change (evolution) but takes population out of. Always happening even if the population isn"t small, bottlenecking or founder"s effect: can be weak or very strong.
