Biology 1001A Lecture Notes - Lecture 8: Ovulation, Hox Gene, Genetic Recombination
Document Summary
Bases can assume rare tautomeric forms and pair improperly. Dna polymerase cannot distinguish between thymine and 5-bromouracil (they are analogues) So polymerase can put 5-bromouracil into your dna. 5-bromouracil is not switches its tautomer very often very mutagenic (chemical mutagen) In/del mutation mechanism one or two base pairs missing or added. If there are so many of the same nucleotide in a row, one of the nitrogenous bases can slip out (streisinger model in the video) replication slippage. It can happen in the new strand or the template strand opposite consequences. Slippage on the new strand adds in an extra base pair. Slippage on the old strand ends up losing a base pair (deletion) Dna replication is a method of generating diversity. It"s a mechanism of sameness, as well as a mechanism of difference. Radiation = mechanism of mutation but vast majority of radiation we are exposed to comes from terrestrial and cosmic environment (not nuclear radiation)