Biology 1001A Lecture Notes - Lecture 8: Retrotransposon, Transposable Element, Dna Replication
Document Summary
Online mc assessment tues evening 6pm to thursday, 2 chances. Repairing double stranded breaks create copy number variations in a genome. Venter"s individual genome sequence showed 1. 2 million variants. 1/4 of variations are snps (single nucleotide polymorphism) 3/4 are cnv, inversion etc. (copy number variants) Each person has about 1000 cnv affecting 35% of genes. Each person has about 300 variants in insertion of retro elements (eg. Our genomes are different because of things that move around think of our genome as a ecosystem that are effected by mobile elements. Bacterial elements code for their mobility (transposase) In bacteria transposase know how to get themselves copied. Transposase is a recombinase, cuts the dna backbone to initiate the replication and movement. Insertion sequences codes for their own mobility, moves around in the genome. If there are 2 insertion sequences close to each other they can move the dna between them (called a transposon) anywhere in a prokaryote.
