Biology 3592A Lecture Notes - Lecture 17: Whole Genome Sequencing, Homologous Chromosome, Mendelian Inheritance
10 May 2020
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Document Summary
Co-inheritance of disease phenotype with known genetic markers. Assessing prevalence of genetic markers in case vs control populations. Whole genome sequencing: family or population rare or lethal disorders. In meiosis i homologous chromosome pairs exchange homologous segments. Patchwork of alternating segments of maternal and paternal xms: mix of 4 grandparents on maternal xm. Can"t determine maternal/paternal by cytogenetic we can by using genetic markers. Genetics markers: any characteristic located in the same position on homologous chromosomes (alleles) which allows us to distinguish one from the other. On different xms they will independently assort trace the markers using pcr. Will produce 4 possible combinations of alleles: 2 parental and 2 non-parental. 2 different ways to line up during meiosis independent assortment of alleles. Independent assortment of alleles on the same chromosome. If no crossover occurs between loci: gametes will be parental, but this usually never happens.
