Biology 3592A Lecture Notes - Lecture 16: Epigenetics, Chromosome, Sampling Bias
10 May 2020
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Document Summary
Complex disorders: due to multiple loci as well as the environment (epigenetics) Cause of premature mortality in almost 2/3 or all individuals (more frequent than large scale chromosome arrangements more likely to result in live birth) Inheritance generally doesn"t follow mendelian pattern this only works for single gene disorders: complex interaction of genetics and the environment, harder to detect vs. Family members share a greater proportion of genetics than random individuals. Family members also share greater proportion of environmental exposures than random individuals. Similar gene=gene and gene-environment interactions: basis of comparison with general population. Patients of a disease compare to normal controls: family history of disease, environment, assess possible genetic contribution. Risk ratios: dependent on a given relationship (i. e. that of siblings) i. e. if your sibling has schizophrenia, you"re 12x more likely than the general population to get schizophreniza. Any number over 1 shows familial aggregation for this trait.
