Biology 3338A Lecture Notes - Lecture 14: Delamination, Catenin, Gastrulation

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We are looking at the bottom side of the embryos. You can see that b catenin is found in the cells of micromeres (in there nucleus). For b catenin signalling you need a cascade to get it in the nucelus. But here its already in the nucleus (we don"t know why). Point is; micromeres have b catenin in them the others don"t. catenin is a tf. Up to this point all you"ve been doing is cell division. The cells that have b catenin in them, these cells therefore turn on genes that the other cells cant. They turn on genes involved in inducing mesoderm and cell movement. If you put b catenin in all nuclei you form an embryo whose all cells try to become mesoderm, and all are moving (gastrulation) ( no good) If you get rid of b catenin nothing becomes mesoderm (only get ectoderm). So you need b catenin, in the right place (micromeres).

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