Biology 2581B Lecture 2: kohalmi notes
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What is a mutation: a change in dna sequence can be inherited. What is a mutant: an organism that experiences a change in dna sequence. How can you tell between mutant and wild type: what is considered the norm wt, what is more frequent wt, who was first wt, who displays a negative effect m. Base pair substitutions replacement of a base pair of nucleotides in a dna sequence with another base pair transitions: substitution of a purine to a purine or pyrimidine to a pyrimidine: 2 transitions: C t transversion: substitution of a purine to a pyrimidine or vice versa: 4 transversions: Fluctuation test results an assay for the detection of mutation induction in bacteria by chemicals test results disprove the first hypothesis: that mutations occur in response to a stimulus. Replica plating penicillin resistant colonies grow in the same position on all three plates meaning the mutation was already present prior to adding the stimulus.