Biology 2581B Lecture Notes - Lecture 9: Nonsense Mutation, Genetic Drift, Mutation Rate

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Mutation rate influenced by: likelihood of: dna change, repair, detection: gametes have 50 new mutations that weren"t inherited from parents passed onto offspring (100 new mutations, mutations are high in virus highest in viroids. Spectrum of snp in human populations: european vs africa. No colour=same -red=first pop is higher -blue=2nd pop is higher. Mutation landscape is phenotypes, particular mutation that intro into genome that is phenotype that arise from genotype. Diff people of populations intro diff landscapes of snps into there genome (variability) Genetic drift: influence allele freq in next generation due to chance if mutation freq is genetically controlled and arose in small pop. Might persist by drift (more powerful then selection on allele) Allele that decrease fitness might still increase pop as long as small. Missense mutation: snp change meaning of codon which create diff aa and protein which may/not have effect on phenotype.

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