Biology 2581B Lecture Notes - Lecture 13: Cri Du Chat, Chromosome, Synteny
26 Mar 2014
School
Department
Course
Professor
Document Summary
After both genomes were sequenced, each mouse chromosome could be pieced together different human chromosomes. D-segments, j- segments: recombination aligns these segments close together this is what increases the number of different antibodies that our bodies can generate, rearrangements of chromosomes are part of a normal event, as seen here. If there is a lack of diversity in making antibodies, it can lead to a shift in the formation of t and b cell clones: often observed in lymphomas. If recombination is not able to occur, you are disturbing the production of antibodies. Large deletions leads to the loss of 10s or 100s of genes: can be caused by x-ray or other chromosome damaging agents that break the dna backbone. If deletion is large enough, it impedes on the bending pattern. Wolf hirschhorn syndrome: deletion from the short arm of chromosome 4.
