Biology 2382B Lecture Notes - Lecture 10: Protein Kinase A, Adenylyl Cyclase, Muscarinic Acetylcholine Receptor
4 Apr 2016
School
Department
Course
Professor
Document Summary
Camp, epithelial cell cl- channels, pka, creb. Ca2+, ip3, dag, pkc, no, cgmp, pkg. Acivaion of muscarinic acetylcholine receptor and k+ channels heart. Someimes you want to speed up or slow down the heart. When slowing down heart, you will have producion of. When acive, they will cause elux of k. We have binding of acetylcholine to gpcr (muscarinic acetylcholine receptor), and promotes associaion of trimeric complex. The gdp bound to ga subunit is displaced, allowing gtp to bind, promoing dissociaion of ga subunit from gby and receptor itself. In this case, instead of ga subunit binding to efector, it is the gby subunit efector (which in this case is the k+ channel) in the acetylcholine (gpcr) muscle contracion this binding to. Once the gby subunit is freed from alpha, it binds to k+ channel, causing the channel to open (cellular hyperpolarizaion), and an elux of k+ rushes out into exterior and slows down the heart.
