Biology 2382B Lecture Notes - Lecture 5: Cell Adhesion Molecule, Adherens Junction, Tight Junction
4 Apr 2016
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Cell juncions, cell adhesion, and the extracellular matrix. You have an epithelial cell (such as in the skin or gut) There is a top surface (apical [side opposite the base] surface) exposed to outside. There is a botom basal part exposed to ecm. Cell atached via desmosomes and hemidesmosomes, which involve ifs. There are adherens juncions, focal adhesions, gap juncions, ight juncions. A juncion is not necessarily strong, whether they"re ight or gap. Cells are connected to e/o via gap juncions: a channel that connects the cytoplasm from one cell to another cell. Epithelial cells are interconnected by gap juncions that allows small molecules to pass through them. Gap juncions are made up of a protein called connexin. 6 connexins form a connexon on one cell. Two cells come together to form a gap juncion. So together there are 12 connexins in a gap juncion. Many dif types of connexins (ideniied by molecular weight)
