Biology 2382B Lecture Notes - Lecture 10: Gm1, Phosphodiesterase, Sildenafil
22 Apr 2014
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Learning objectives: gpcrs fast acting effectors k+ channels, gpcrs that regulate adenylyl cyclase. Camp, epithelial cell cl- channels, pka, creb. All of these are 2nd messengers: gpcrs that activate phospholipase c. Ca2+, ip3, dag, pkc, no, cgmp, pkg. In different contexts different effectors and secondary messengers can be produced. Activation of muscarinic acetylcholine receptor and k+ channels in the heart. Beta-gamma subunit is the one that is freed and goes on to activate the: exception: effector k+ channel protein, potassium channel opens and the k+ ions leave the cells to slow the heart rate. Regulation of adenylyl cyclase: adenylyl cyclase: effector enzyme associated with trimeric g protein complex. It catalyzes formation of cyclic amp (camp): major second messenger. The only ligand we need to worry about is epinephrine: depending on the ligand-receptor complex you can have either increased camp or decreased camp, gpcr/camp pathway is very common in many mammalian cells.
