Biology 2382B Lecture Notes - Lecture 17: Transmembrane Domain, Protein Kinase, Ras Subfamily
Document Summary
Receptor tyrosine kinases (rtks: transmembrane domain, have and ecd, which is the ligand binding domain. Sometimes you can get direct activation of transcription factors, sometimes it is through a pathway, sometimes it can target other proteins: kinase domain in cytoplasm can activate tf, going to talk about growth factors, ras/map pathway etc. Dimerization allows for trans-autophosphorylation of cytoplasmic domains. Single protein , one tmd, extra-cellular ligand binding domain, and has a poorly active protein kinase activity. Phosphoryated tyrosines are a recruitment signals for adapter protein complexes and they are recognized by protein tyrosine binding domains, referred to as sh2 domains. Adapter proteins contains unique domains that recognize specific sequences. Sh2 -src homology 2 domain (src is an acronym for sarcoma) Sh2 domains present in at least 100 human proteins: these adapter proteins have these unique sequences which are conserved, and shared with many other proteins. Sh2 src homology 2 domains, shared with 100 human proteins.