Biology 2382B Lecture Notes - Lecture 15: Shap, Mitosis, Plectin
11 Mar 2017
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Document Summary
Actin and tubulin tend to be very dynamic. Subunits have to be in a certain energetic state. Actin and mts do not provide great tensile strength. Thus intermediate filaments are used to link things together and give tissues strength. These are migrating cells cell is migrating, therefore the cell will have focal adhesions and activing proteins (cdc42, rac and rho) Intermediate filaments found in the axons of neurons. Providing tensile strength of the axon (as well as organization) Intermediate filaments are diagnostically helpful because it can help identify origins of cancer cells. Two proteins (dimers) come together to form a tetramer. Two head and tail domains on one side, and two on the other. This has no polarity, thus the intermediate filament has no polarity. Ifs are in dynamic state - proteins within filament are exchanged. Not as fast as the other two, but it does change with time.
