Biology 2382B Lecture Notes - Lecture 5: Adenylyl Cyclase, Protein Kinase C, Transferrin Receptor
18 Oct 2016
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Document Summary
Method of selective internalization of specific extracellular molecules (ligands). It is also used to bring back surface proteins that were originally sent by the cell. i. e ldls, transferrin, hormones etc. Lipids transported in large water soluble complexes called lipoproteins. Contain ~88% cholesteryl esters; mediate cholesterol transport. Amphipathic: polar/hydrophilic on the surface; non-polar/hydrophobic inside: polar surface allows entry into blood, ldl carries cholesterol to cells bad; (hdl brings cholesterol to liver) Ldl receptors (ldlr) located on plasma membrane (clathrin-coated pits: 2-layer coat: clathrin and adapter proteins (ap) Ap1 at trans golgi nucleus (going to late endosome) *ap recognizes sorting signals of cargo proteins or receptors: dynamin used by vesicles to change shape and pinch off, dynamin uses gtp hydrolysis; forms are ring around the vesicle neck. *dynamin and gtp is present wherever vesicles are formed: cytoplasmic domain: coat-proteins; removed by gtp hydrolysis --> exposes snares.
