Biochemistry 3386B Lecture Notes - Lecture 28: Acute Pancreatitis, Unstable Angina, Skeletal Muscle
3 Mar 2015
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Routinely used enzymes and cardiac markers* (this is just a summary sheet, please follow notes for details: dr v bhayana) Ck-bb is high in brain, prostate, gut, lung, bladder, uterus. Ck-mm is high in skeletal and cardiac muscle. Ck-mb is 25-46% of the ck activity in heart. Present in cytoplasm of all cells, high activity in heart, liver and skeletal muscle. Ld-1and ld-2 high in heart; ld5 high in liver or skeletal muscle. Two subunits m and b; three isoenzymes, ck-bb, -mb and mm, also known as. Ck-mb is also reported as the percentage of total ck improves specificity. Mw 134 kda; two subunit constitute five isoenzymes. Myocardial infarction and risk stratification in unstable angina patients. Stays elevated in blood for 5-7 days after the infarction. 17,800 da; high sensitivity for ami, poor specificity. Rises in blood very early after the infarction. Lipase acts on long chain triglycerides improved specificity by modifying assaying conditions.
