Biochemistry 2280A Lecture Notes - Pentose Phosphate Pathway, Glycogen Synthase, Allosteric Regulation

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Dna, rna: glycogen synthesis and breakdown, glycolysis and fermentation, gluconeogenesis, pentose phosphate pathway. + 2 pi (like atp, utp can be used as an energy source) Neither atp nor amp regulate glycogen phosphorylase in liver. Control by phosphorylation in liver & muscle glycogen synthase. Insulin leads to dephosphorylation in liver & muscle: glucagon leads to phosphorylation in liver, epinephrine leads to phosphorylation in liver & muscle. Glucose + 2 adp + 2 pi + 2 nad+ (other monosaccharides can also feed into the pathway) 2 pyruvate + 2 atp + 2 nadh. Targets for control of flux y g r e n e e e r f s b b. Metabolite(s: steps 1, 3 and 10 are targets for control of flux through glycolysis. Strategy 1: formation of lactate: pyruvate is reduced to lactate while nadh is oxidized to nad, micro-organisms, some eukaryotic cells (e. g. , muscle during intense exercise)

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