Biochemistry 2280A Lecture Notes - Lecture 6: Cell Nucleus, Nucleosome, Telomere

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Learning outcomes: explain the chemical structure of nucleotides without memorizing the structures of the bases, describe b-dna and the higher order structures formed by rna, and the important forces that stabilize these structures. Dna and rna are both linear polymers composed of deoxyribonucleotides and ribonucleotides, which consist of a monosaccharide, a nitrogenous base, and phosphate(s). Nitrogenous bases: all nitrogenous bases are hydrophobic. Pyrimidines: uracil is identical to thymine except it lacks a methyl group, nitrogenous bases are linked to the 1" carbon of the sugar by a n-glycosidic bond, a sugar bound to a base is called a nucleoside. Phosphates: attach to the 5" position of ribose or deoxyribose by a phosphodiester bond, a phosphate, sugar, and base all bonded together forms a nucleotide. \nucleotides are the building blocks of nucleic acids. Z dna: not found in nature, left handed (counter clockwise) B dna: most common form, right handed (clockwise, found in the cell, 10 base pairs/turn.

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