Biochemistry 2280A Lecture Notes - Lecture 11: Flavoprotein, Cytochrome, Succinate Dehydrogenase

• School: Western University
• Department: Biochemistry
• Course: Biochemistry 2280A
• Professor: Derek Mc Lachlin

Document Summary

Topic 11 learning objectives: five mitochondrial electron carriers, process of electron transport, energy flow from electron carriers to atp, mechanism of atp synthase, stoichiometry of proton movement and atp synthesis. An aside: cofactors: cofactor = protein-bound non-protein chemical. Aka substrate: primarily they are metal ions like iron. Different metal groups are required: p(cid:396)ostheti(cid:272) g(cid:396)oup (cid:272)ould (cid:271)e (cid:373)etal io(cid:374) o(cid:396) (cid:272)oe(cid:374)z(cid:455)(cid:373)e, (cid:271)ut defi(cid:374)i(cid:374)g thi(cid:374)g is that it"s tightly bound. Prosthetic groups are more or less permanently associated with the protein/enzyme. Overview of electron transport: nadh and fadh2 come from citric acid cycle. They give up electrons to the electron transport chain, which has several protein complexes found in the inner mitochondrial membrane: electrons are transferred through a series of electron acceptors. Ultimately they end up with oxygen to make water: nad+ and fad are released back to the citric acid cycle, this process like any chemical process is energetically favourable.