Biochemistry 2280A Lecture Notes - Lecture 12: Mitochondrion, Glycolysis, Hyperglycemia

• School: Western University
• Department: Biochemistry
• Course: Biochemistry 2280A
• Professor: Derek Mc Lachlin

Document Summary

Topic 12: acetyl-coa 2: fatty acids, ketone bodies, and biosynthesis. Topic 12 learning objectives: fates of acetyl-coa, roles of mitochondrion, fatty acid synthesis and degradation, ketone bodies, regulation of fat metabolism. Release of acetyl-coa from fatty acid storage: low glucose conditions, break down triacylglycerols to fatty acids; fatty acids make acetyl coa citric acid cycle to etc and make atp, process of fatty acid to acetyl-coa is called beta oxidation. Triacylglycerol breakdown in adipocyte: lipase breaks down the triacylglycerol; removes fatty acids from glycerol, key point of regulation. If we have lots of glucose, (cid:449)e do(cid:374)"t (cid:374)eed to (cid:271)(cid:396)eak do(cid:449)(cid:374) fatty acid storage. Under low glucose conditio(cid:374)s, li(cid:448)e(cid:396)"s (cid:373)ai(cid:374) sou(cid:396)(cid:272)e of energy is fatty acids; not glucose: likewise the muscle will do the same thing; uses fatty acids to break down into acetyl coa. Amp; one of those stubborn reactions requiring extra energy to make them go. In the end you have activated fatty acid.