Biochemistry 2280A Lecture Notes - Hemoglobin, Exon, Polyadenylation
3 Feb 2013
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Primary transcript becomes a mrna for export out of the nucleus and translation. 5 end first nucleotide added phosphate then a 7 methyl guanosine through a 5"-5" linkage. Req for translation of mrna into protein (translation initation) Downstream the aaaaa seq signals a cleavage from the actual rna ending and after 30 base pairs poly a tail to be added on. Helps protect 3 end of mrna from degradation. Indicates that 3 end of mrna is intact and therefore is important for export out of nucleus and for translation. Coding called exons non coding called introns. In eukaryotic cells protein encoding seq are interrupted by one or more noncoding deq called introns. Full gene is 200,000 pairs but most is thrown out to make globin gene. Reason is cause its not the introns can sometimes be used to actually make other mrna proteins. Signal rna can be spliced in diff ways to create related but distinct proteins.
