Biochemistry 2280A Lecture Notes - Lecture 4: Triple Helix, Hydroxyproline, Fibril
15 Jan 2017
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Topic 4 - protein function and enzymes (pt. Most common protein in animals (25% - 30%) Made and lives outside of the cell. Pound for pound - it"s stronger than steel. Found is many products in the marketplace. Cheap and abundant not because it has intrinsic features. 3 polypeptides braided together into a microfibril. An aggregation of collagen fibril forms a collagen fiber. Mainly consists of proline, hydroxyproline and glycine. The peptide nh provides h for hydrogen bonds. It is also the smallest amino acid so it doesn"t interfere with how the 3 chain pack together (essential!!) Hydroxyproline: a modified amino acid with hydroxyl group) Hydroxylation of proline help stabilize the triple helix. Oh groups can form hydrogen bonds help keep the triple helix. Oh serves as thes site of sugar addition. Involved in cross-link reaction that creates covalent bonds between collagen fibrils.
