Biochemistry 2280A Lecture Notes - Lecture 11: Glycogen Phosphorylase, Pentose Phosphate Pathway, Glycogen Synthase

• School: Western University
• Department: Biochemistry
• Course: Biochemistry 2280A
• Professor: Derek Mc Lachlin

Document Summary

Learning objectives: fates of glucose-6-phosphate, glycogen synthesis and degradation, glycolysis and gluconeogenesis, regulation of carbohydrate metabolism, fermentation, pentose phosphate pathway, energetics of opposite pathways. Carbohydrate metabolism: glycogen synthesis and breakdown, glycolysis and fermentation, gluconeogenesis, pentose phosphate pathway. Glucose-6-phosphate glucose-1-phosphate glycogen: glucose-1-phosphate to glycogen done by glycogen synthase, utp to udp + 2pi (an atp equivalent) where utp is an energy source, glycogen phosphorylase: removes glucose 1 phosphate from glycogen (at end) Suppose glucose-6-phosphate (g6p) allosterically regulates both glycogen synthase and glycogen phosphorylase in skeletal muscle. We want to increase one and decrease the other- regulate in opposite ways ie. an increase in glycogen synthase and a decrease in glycogen phosphorylaase: when g6p is high we want to store it into glycogen! Allosteric regulation in liver: when atp is high we don"t need to touch glycogen storage, when amp is high atp is low activates glycogen phosphorylase, high levels of amp mean there isn"t enough atp and need more.