Biochemistry 2280A Lecture 11: Lec 11 - Carbohydrate Metabolism
28 Oct 2016
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What to eat the day before a marathon: pasta, carbohydrate loading, long distance runners will eat high carbohydrate foods. Carbohydrate metabolism: glycogen synthesis and breakdown, glycolysis and fermentation, gluconeogenesis: making glucose, pentose phosphate pathway. Pathway starts at glucose-6-phosphate: 2 reactions in pathway, move phosphate from position 6 to 1, equilibrium process: g is near 0. Addition of glucose-1-phosphaye to glycogen is catalyzed by glycogen synthase: glycogen: polymer with many glucose subunits bound together, glycogen synthase synthesizes glycogen. Reaction to glycogen needs to be driven forward, utp used (not atp: utp has 3 phosphates just like atp similar hydrolysis reaction, utp atp equivalent. Utp converted to udp + 2 pi: energetically favorable reaction g < 0, 1 phosphate from utp and one from glucose-1-phosphate. No phosphate in glycogen: energetically favorable reaction. When want to break down glycogen: want to release glucose monomers, g is < 0 so glycogen synthase is not a good enzyme for this reverse process.
