Anatomy and Cell Biology 4451F/G Lecture Notes - Lecture 22: Frontal Lobe, Amyloid Precursor Protein, Excitotoxicity

• School: Western University
• Department: Anatomy and Cell Biology
• Course: Anatomy and Cell Biology 4451F/G
• Professor: Suzanne Schmid

Document Summary

Lecture 22 neuroinflammation: implications in ad and stroke guest: whitehead. You get a loss of brain tissue because a vessel that normally gives oxygen/glucose/nutrient rich blood to that tissue becomes blocked. Locally at vessel level build up of plaque. Ischemic stroke: build up of plaque at vessel nowhere near brain (leg) clot becomes destabilized, dislodges, travels through vasculature and gets stuck in brain artery/vessel, get blockage, no blood in that tissue so neurons die. Ischemic stroke: hemorrhagic stroke, burst of blood vessel, since vessel lost integrity, lack of blood to brain tissue. Both ischemic and hemorrhagic: get rapid cell death, end up with infarccter or necrotic core. Forms hole in brain infarct a bunch of necrosis. Loss of tissue in that region: get loss of blood in necrotic core and what also happens is that areas around necrotic core (called periinfarcter/conumbra?)